The rehabilitation medicine program, known as enotherapy or wine treatment, uses red wine extract without ethanol to suppress oxidative stress, a precursor to many diseases, as part of antioxidant therapy. Red wine improves intestinal microbiota and benefits health through its antioxidants, vitamins, and trace elements. Red wine’s high antioxidant activity surpasses other beverages due to its flavonoids, phenolic acids, stilbenes, lignans, proanthocyanidins, and compounds like resveratrol, quercetin, dihydroxytyrosol, melatonin, and aspirin. Red wine extract without ethanol can also be included in therapeutic nutrition.